Laboratory of Experimental Immunology

Our Laboratory focuses on human immunology with a strong interest in the development of B lymphocytes and antibodies. In particular, we are interested in the antibody response to HIV-1, HCV, HCMV, SARS-CoV-2 and other infectious pathogens. We aim to precisely understand the biology of humoral immunity and to use this knowledge to effectively prevent and treat infectious diseases. To this end, our laboratory works with a wide range of techniques in molecular biology, immunology, and virology. Moreover, we conduct early phase clinical trials to translate our findings into clinical applications. Our group is dedicated to provide an excellent work environment and to pursue forefront and innovative research.


Our Laboratory is located at the Center for Molecular Medicine Cologne (CMMC) on the campus of the University of Cologne. In order to carry out a wide range of experiments in molecular biology, immunology, and translational research, the laboratory is using BSL-1/-2/-3 work spaces, BSL-2 Cell Sorting, a BSL-2 Sample Processing lab, and a BSL-3** Hu-Mouse Core.

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Basic Research

Using forefront technologies, we aim to identify biological principles of human B cell development and the generation of antibodies. On a molecular level, we investigate and decipher the antibody response against infectious pathogens (e.g. Human Immunodeficiency Virus 1, Ebola Virus, Hepatitis C Virus, SARS-CoV-2) and study antibody and pathogen interaction and characteristics.

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Translational Research

We undertake strong efforts to translate novel findings into clinical application to improve prevention and therapy of infectious diseases. To this end, our laboratory performs clinical trials at the highest ethical and professional standards. We closely work with our clinical partners at the University Hospital of Cologne, and other national and international sites.

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Klein Lab Video