Antibodies are glycoproteins that are generated by the human body to eliminate pathogens, such as viruses and bacteria. Antibodies are also be elicited by vaccines and protect us from a number of infections, such as poliomyelitis, measles, or Hepatitis B. However, effective vaccines against HIV-1, HCV, and a number of other infectious pathogens are still missing.
Our laboratory investigates the antibody response against infectious pathogens in order to develop novel vaccination strategies and to establish antibody-mediated therapies to effectively treat severe infections. To this end, we aim to identify the biological principles of humoral immunity and to use this knowledge to effectively prevent and treat infectious diseases. Our laboratory works with a wide range of techniques in molecular biology as well as conducts clinical trials to translate our findings into clinical applications.