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Publications


2017


Nishimura Y., Gautam R., Chun T.W., Sadjadpour R., Foulds K.E., Shingai M., Klein F., Gazumyan A., Golijanin J., Donaldson M., Donau O.K., Plishka R.J., Buckler-White A., Seaman M.S., Lifson J.D., Koup R.A., Fauci A.S., Nussenzweig M.C., Martin M.A., Early antibody therapy can induce long-lasting immunity to SHIV.
Nature. (2017). read more


Gruell H. and Klein F., Progress in HIV-1 antibody research using humanized mice.
Curr Opin HIV AIDS. (2017). readmore


Caskey M.*, Schoofs T.*, Gruell H.*, Settler A., Karagounis T., Kreider E.F., Murrell B., Pfeifer N., Nogueira L., Oliveira T.Y., Learn G.H., Cohen Y.Z., Lehmann C., Gillor D., Shimeliovich I., Unson-O’Brien C., Weiland D., Robles A., Kümmerle T., Wyen C., Levin R., Witmer-Pack M., Eren K., Ignacio C., Kiss S., West A.P., Mouquet H., Zingman B.S., Gulick R.M., Keler T., Bjorkman P.J., Seaman M.S., Hahn B.H., Fätkenheuer G., Schlesinger S.J., Nussenzweig M.C.*, Klein F.*, Antibody 10-1074 suppresses viremia in HIV-1-infected individuals.
Nat Med. (2017). read more


2016


Caskey, M., Klein, F., Nussenzweig, M.C., Broadly Neutralizing Antibodies for HIV-1 Prevention or Immunotherapy.
N Engl J Med. (2016). read more


Gristick, H.B., von Boehmer, L., West, A.P. Jr, Schamber, M., Gazumyan, A., Golijanin, J., Seaman, M.S., Fätkenheuer, G., Klein, F., Nussenzweig, M.C., Bjorkman, P.J.,. Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4- binding site.
Nat Struct Mol Biol. (2016). read more


Scheid, J.F.*, Horwitz, J.A.*, Bar-On, Y., Kreider, E.F., Lu, C.L., Lorenzi, J.C., Feldmann, A., Braunschweig, M., Nogueira, L., Oliveira, T., Shimeliovich, I., Patel, R., Burke, L., Cohen, Y.Z., Hadrigan, S., Settler, A., Witmer-Pack, M., West, A.P. Jr, Juelg, B., Keler, T., Hawthorne, T., Zingman, B., Gulick, R.M., Pfeifer, N., Learn, G.H., Seaman, M.S., Bjorkman, P.J., Klein, F., Schlesinger, S.J., Walker, B.D., Hahn, B.H., Nussenzweig, M.C., HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption.
Nature. (2016). read more


Schoofs, T.*, Klein, F.*, Braunschweig, M.*, Kreider, E.F., Feldmann, A., Nogueira, L., Oliveira, T., Lorenzi, J.C., Parrish, E.H., Learn, G.H., West, A.P. Jr, Bjorkman, P.J., Schlesinger, S.J., Seaman, M.S., Czartoski, J., McElrath, M.J., Pfeifer, N., Hahn, B.H., Caskey, M., Nussenzweig, M.C., HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1.
Science. (2016). read more


Gautam, R., Nishimura, Y., Pegu, A., Nason, M.C., Klein, F., Gazumyan, A., Golijanin, J., Buckler-White, A., Sadjadpour, R., Wang, K., Mankoff, Z., Schmidt, S.D., Lifson, J.D., Mascola, J.R., Nussenzweig, M.C., Martin, M.A., A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges.
Nature. (2016). read more


Akkina, R.K., Allam, A., Balazs, A.B., Blankson, J., Burnett, J.C., Casares, S., Garcia, J.V., Hasenkrug, K., Kashanchi, F., Kitchen, S., Klein, F., Kumar, P., Luster, A.D., Poluektova, L.Y., Rao, M., Sanders, B.E., Shultz, L.D., and JA, Z., Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary.
AIDS Res Hum Retroviruses. (2016). read more


2015


Lee, J.H., Leaman, D.P., Kim, A.S., Torrents de la Pena, A., Sliepen, K., Yasmeen, A., Derking, R., Ramos, A., de Taeye, S.W., Ozorowski, G., Klein, F., Burton, D.R., Nussenzweig, M.C., Poignard, P., Moore, J.P., Klasse, P.J., Sanders, R.W., Zwick, M.B., Wilson, I.A., and Ward, A.B., Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike.
Nat Commun (2015). read more


Cohn, L.B., Silva, I.T., Oliveira, T.Y., Rosales, R.A., Parrish, E.H., Learn, G.H., Hahn, B.H., Czartoski, J.L., McElrath, M.J., Lehmann, C., Klein, F., Caskey, M., Walker, B.D., Siliciano, J.D., Siliciano, R.F., Jankovic, M., and Nussenzweig, M.C., HIV-1 integration landscape during latent and active infection.
Cell. (2015). read more


Gruell, H. and Klein, F., Mögliche Strategien zur HIV-Prävention und -Therapie.
MMW Fortschr Med. (2015).


Freund, N.T., Horwitz, J.A., Nogueira, L., Sievers, S.A., Scharf, L., Scheid, J.F., Gazumyan, A., Liu, C., Velinzon, K., Goldenthal, A., Sanders, R.W., Moore, J.P., Bjorkman, P.J., Seaman, M.S., Walker, B.D., Klein, F., and Nussenzweig, M.C., A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo.
PLoS Pathog. (2015). read more


Caskey, M.*, Klein, F.*, Lorenzi, J.C., Seaman, M.S., West, A.P., Jr., Buckley, N., Kremer, G., Nogueira, L., Braunschweig, M., Scheid, J.F., Horwitz, J.A., Shimeliovich, I., Ben-Avraham, S., Witmer-Pack, M., Platten, M., Lehmann, C., Burke, L.A., Hawthorne, T., Gorelick, R.J., Walker, B.D., Keler, T., Gulick, R.M., Fatkenheuer, G., Schlesinger, S.J., and Nussenzweig, M.C., Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117.
Nature. (2015). read more


Zolla-Pazner, S., Cohen, S.S., Boyd, D., Kong, X.P., Seaman, M., Nussenzweig, M., Klein, F., Overbaugh, J., and Totrov, M., Structure/Function Studies Involving the V3 Region of the HIV-1 Envelope Delineate Multiple Factors that Affect Neutralization Sensitivity.
J Virol. (2015). read more


2014


Bournazos, S., Klein, F., Pietzsch, J., Seaman, M.S., Nussenzweig, M.C., and Ravetch, J.V., Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in vivo activity.
Cell. (2014). read more


Halper-Stromberg, A., Lu, C.L., Klein, F., Horwitz, J.A., Bournazos, S., Nogueira, L., Eisenreich, T.R., Liu, C., Gazumyan, A., Schaefer, U., Furze, R.C., Seaman, M.S., Prinjha, R., Tarakhovsky, A., Ravetch, J.V., and Nussenzweig, M.C., Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice.
Cell. (2014). read more


Klein, F., Nogueira, L., Nishimura, Y., Phad, G., West, A.P., Jr., Halper-Stromberg, A., Horwitz, J.A., Gazumyan, A., Liu, C., Eisenreich, T.R., Lehmann, C., Fatkenheuer, G., Williams, C., Shingai, M., Martin, M.A., Bjorkman, P.J., Seaman, M.S., Zolla-Pazner, S., Karlsson Hedestam, G.B., and Nussenzweig, M.C., Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants.
J Exp Med. (2014). read more


Gruell, H. and Klein, F., Opening Fronts in HIV Vaccine Development: Tracking the development of broadly neutralizing antibodies.
Nat Med. (2014). read more


West, A.P., Jr., Scharf, L., Scheid, J.F., Klein, F., Bjorkman, P.J., and Nussenzweig, M.C., Structural insights on the role of antibodies in HIV-1 vaccine and therapy.
Cell. (2014). read more


Shingai, M., Donau, O.K., Plishka, R.J., Buckler-White, A., Mascola, J.R., Nabel, G.J., Nason, M.C., Montefiori, D., Moldt, B., Poignard, P., Diskin, R., Bjorkman, P.J., Eckhaus, M.A., Klein, F., Mouquet, H., Cetrulo Lorenzi, J.C., Gazumyan, A., Burton, D.R., Nussenzweig, M.C., Martin, M.A., and Nishimura, Y., Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques.
J Exp Med. (2014). read more


2013


Klein, F., Mouquet, H., Dosenovic, P., Scheid, J.F., Scharf, L., and Nussenzweig, M.C., Antibodies in HIV-1 vaccine development and therapy.
Science. (2013). read more


Shingai, M., Nishimura, Y., Klein, F., Mouquet, H., Donau, O.K., Plishka, R., Buckler-White, A., Seaman, M., Piatak, M., Jr., Lifson, J.D., Dimitrov, D.S., Nussenzweig, M.C., and Martin, M.A., Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia.
Nature. (2013). read more


Klein, F., Diskin, R., Scheid, J.F., Gaebler, C., Mouquet, H., Georgiev, I.S., Pancera, M., Zhou, T., Incesu, R.B., Fu, B.Z., Gnanapragasam, P.N., Oliveira, T.Y., Seaman, M.S., Kwong, P.D., Bjorkman, P.J., and Nussenzweig, M.C., Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization.
Cell. (2013). read more


Malbec, M., Porrot, F., Rua, R., Horwitz, J., Klein, F., Halper-Stromberg, A., Scheid, J.F., Eden, C., Mouquet, H., Nussenzweig, M.C., and Schwartz, O., Broadly neutralizing antibodies that inhibit HIV-1 cell to cell transmission.
J Exp Med. (2013). read more


West, A.P., Jr., Scharf, L., Horwitz, J., Klein, F., Nussenzweig, M.C., and Bjorkman, P.J., Computational analysis of anti-HIV-1 antibody neutralization panel data to identify potential functional epitope residues.
Proc Natl Acad Sci U S A. (2013). read more


Diskin, R., Klein, F., Horwitz, J.A., Halper-Stromberg, A., Sather, D.N., Marcovecchio, P.M., Lee, T., West, A.P., Jr., Gao, H., Seaman, M.S., Stamatatos, L., Nussenzweig, M.C., and Bjorkman, P.J., Restricting HIV-1 pathways for escape using rationally designed anti-HIV-1 antibodies.
J Exp Med. (2013). read more


Barouch, D.H., Whitney, J.B., Moldt, B., Klein, F., Oliveira, T.Y., Liu, J., Stephenson, K.E., Chang, H.W., Shekhar, K., Gupta, S., Nkolola, J.P., Seaman, M.S., Smith, K.M., Borducchi, E.N., Cabral, C., Smith, J.Y., Blackmore, S., Sanisetty, S., Perry, J.R., Beck, M., Lewis, M.G., Rinaldi, W., Chakraborty, A.K., Poignard, P., Nussenzweig, M.C., and Burton, D.R., Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys.
Nature. (2013). read more


Horwitz, J.A., Halper-Stromberg, A., Mouquet, H., Gitlin, A.D., Tretiakova, A., Eisenreich, T.R., Malbec, M., Gravemann, S., Billerbeck, E., Dorner, M., Buning, H., Schwartz, O., Knops, E., Kaiser, R., Seaman, M.S., Wilson, J.M., Rice, C.M., Ploss, A., Bjorkman, P.J., Klein, F., and Nussenzweig, M.C., HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice.
Proc Natl Acad Sci U S A. (2013). read more


Hoot, S., McGuire, A.T., Cohen, K.W., Strong, R.K., Hangartner, L., Klein, F., Diskin, R., Scheid, J.F., Sather, D.N., Burton, D.R., and Stamatatos, L., Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bNAbs.
PLoS Pathog. (2013). read more


Guermonprez, P., Helft, J., Claser, C., Deroubaix, S., Karanje, H., Gazumyan, A., Darasse-Jeze, G., Telerman, S.B., Breton, G., Schreiber, H.A., Frias-Staheli, N., Billerbeck, E., Dorner, M., Rice, C.M., Ploss, A., Klein, F., Swiecki, M., Colonna, M., Kamphorst, A.O., Meredith, M., Niec, R., Takacs, C., Mikhail, F., Hari, A., Bosque, D., Eisenreich, T., Merad, M., Shi, Y., Ginhoux, F., Renia, L., Urban, B.C., and Nussenzweig, M.C., Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection.
Nat Med. (2013). read more


Gaebler, C., Gruell, H., Velinzon, K., Scheid, J.F., Nussenzweig, M.C., and Klein, F., Isolation of HIV-1-reactive antibodies using cell surface-expressed gp160Deltac(BaL.).
J Immunol Methods. (2013). read more


2012


Pietzsch, J., Gruell, H., Bournazos, S., Donovan, B.M., Klein, F., Diskin, R., Seaman, M.S., Bjorkman, P.J., Ravetch, J.V., Ploss, A., and Nussenzweig, M.C., A mouse model for HIV-1 entry.
Proc Natl Acad Sci U S A. (2012). read more


Klein, F., Gaebler, C., Mouquet, H., Sather, D.N., Lehmann, C., Scheid, J.F., Kraft, Z., Liu, Y., Pietzsch, J., Hurley, A., Poignard, P., Feizi, T., Morris, L., Walker, B.D., Fatkenheuer, G., Seaman, M.S., Stamatatos, L., and Nussenzweig, M.C., Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein.
J Exp Med. (2012). read more


Klein, F., Halper-Stromberg, A., Horwitz, J.A., Gruell, H., Scheid, J.F., Bournazos, S., Mouquet, H., Spatz, L.A., Diskin, R., Abadir, A., Zang, T., Dorner, M., Billerbeck, E., Labitt, R.N., Gaebler, C., Marcovecchio, P.M., Incesu, R.B., Eisenreich, T.R., Bieniasz, P.D., Seaman, M.S., Bjorkman, P.J., Ravetch, J.V., Ploss, A., and Nussenzweig, M.C., HIV therapy by a combination of broadly neutralizing antibodies in humanized mice.
Nature. (2012). read more


Vehreschild, J.J., Moritz, G., Vehreschild, M.J., Arenz, D., Mahne, M., Bredenfeld, H., Chemnitz, J., Klein, F., Cremer, B., Boll, B., Kaul, I., Wassmer, G., Hallek, M., Scheid, C., and Cornely, O.A., Efficacy and safety of moxifloxacin as antibacterial prophylaxis for patients receiving autologous haematopoietic stem cell transplantation: a randomised trial.
Int J Antimicrob Agents. (2012). read more


Sather, D.N., Carbonetti, S., Kehayia, J., Kraft, Z., Mikell, I., Scheid, J.F., Klein, F., and Stamatatos, L., Broadly neutralizing antibodies developed by an HIV-positive elite neutralizer exact a replication fitness cost on the contemporaneous virus.
J Virol. (2012). read more


2011


Scheid, J.F., Mouquet, H., Ueberheide, B., Diskin, R., Klein, F., Oliveira, T.Y., Pietzsch, J., Fenyo, D., Abadir, A., Velinzon, K., Hurley, A., Myung, S., Boulad, F., Poignard, P., Burton, D.R., Pereyra, F., Ho, D.D., Walker, B.D., Seaman, M.S., Bjorkman, P.J., Chait, B.T., and Nussenzweig, M.C., Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding.
Science. (2011). read more


Mouquet, H., Klein, F., Scheid, J.F., Warncke, M., Pietzsch, J., Oliveira, T.Y., Velinzon, K., Seaman, M.S., and Nussenzweig, M.C., Memory B cell antibodies to HIV-1 gp140 cloned from individuals infected with clade A and B viruses.
PLoS One. (2011). read more


Diskin, R., Scheid, J.F., Marcovecchio, P.M., West, A.P., Jr., Klein, F., Gao, H., Gnanapragasam, P.N., Abadir, A., Seaman, M.S., Nussenzweig, M.C., and Bjorkman, P.J., Increasing the potency and breadth of an HIV antibody by using structure-based rational design.
Science. (2011). read more


2010


Pietzsch, J., Scheid, J.F., Mouquet, H., Klein, F., Seaman, M.S., Jankovic, M., Corti, D., Lanzavecchia, A., and Nussenzweig, M.C., Human anti-HIV-neutralizing antibodies frequently target a conserved epitope essential for viral fitness.
J Exp Med. (2010). read more


2009


Klein, F. and Hallek, M., Does the removal of non-affected lymph nodes of a neoplastic focus weaken the immunologic defense?.
Dtsch Med Wochenschr. (2009). read more


2007


Feldhahn, N., Henke, N., Melchior, K., Duy, C., Soh, B.N., Klein, F., von Levetzow, G., Giebel, B., Li, A., Hofmann, W.K., Jumaa, H., and Muschen, M., Activation-induced cytidine deaminase acts as a mutator in BCR-ABL1-transformed acute lymphoblastic leukemia cells.
J Exp Med. (2007). read more


2006


Klein, F., Feldhahn, N., Herzog, S., Sprangers, M., Mooster, J.L., Jumaa, H., and Muschen, M., BCR-ABL1 induces aberrant splicing of IKAROS and lineage infidelity in pre-B lymphoblastic leukemia cells.
Oncogene. (2006). read more


2005


Feldhahn, N., Klein, F., Mooster, J.L., Hadweh, P., Sprangers, M., Wartenberg, M., Bekhite, M.M., Hofmann, W.K., Herzog, S., Jumaa, H., Rowley, J.D., and Muschen, M., Mimicry of a constitutively active pre-B cell receptor in acute lymphoblastic leukemia cells.
J Exp Med. (2005). read more


Feldhahn, N., Rio, P., Soh, B.N., Liedtke, S., Sprangers, M., Klein, F., Wernet, P., Jumaa, H., Hofmann, W.K., Hanenberg, H., Rowley, J.D., and Muschen, M., Deficiency of Bruton's tyrosine kinase in B cell precursor leukemia cells.
Proc Natl Acad Sci U S A. (2005). read more


Soh, B.N., Klein, F., Feldhahn, N., and Muschen, M., B-lymphoid or myeloid lineage identity of cell lines derived from chronic myeloid leukemia blast crisis.
Cancer Genet Cytogenet. (2005). read more


Klein, F., Feldhahn, N., Mooster, J.L., Sprangers, M., Hofmann, W.K., Wernet, P., Wartenberg, M., and Muschen, M., Tracing the pre-B to immature B cell transition in human leukemia cells reveals a coordinated sequence of primary and secondary IGK gene rearrangement, IGK deletion, and IGL gene rearrangement.
J Immunol. (2005). read more


Klein, F., Feldhahn, N., and Muschen, M., Interference of BCR-ABL1 kinase activity with antigen receptor signaling in B cell precursor leukemia cells.
Cell Cycle. (2004). read more


Klein, F., Feldhahn, N., Harder, L., Wang, H., Wartenberg, M., Hofmann, W.K., Wernet, P., Siebert, R., and Muschen, M., The BCR-ABL1 kinase bypasses selection for the expression of a pre-B cell receptor in pre-B acute lymphoblastic leukemia cells.
J Exp Med. (2004). read more


2003


Klein, F., Feldhahn, N., Lee, S., Wang, H., Ciuffi, F., von Elstermann, M., Toribio, M.L., Sauer, H., Wartenberg, M., Barath, V.S., Kronke, M., Wernet, P., Rowley, J.D., and Muschen, M., T lymphoid differentiation in human bone marrow.
Proc Natl Acad Sci U S A. (2003). read more


Wartenberg, M., Ling, F.C., Muschen, M., Klein, F., Acker, H., Gassmann, M., Petrat, K., Putz, V., Hescheler, J., and Sauer, H., Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species.
FASEB J. (2003). read more