Publications

2022 (selected publications)

Neutralisation sensitivity of the SARS-CoV-2 omicron BA.2.75 sublineage.
Gruell H, Vanshylla K, Tober-Lau P, Hillus D, Sander LE, Kurth F, Klein F.
Lancet Infect Dis (2022)
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SARS-CoV-2 Omicron sublineages exhibit distinct antibody escape patterns.
Gruell H, Vanshylla K, Korenkov M, Tober-Lau P, Zehner M, Münn F, Janicki H, Augustin M, Schommers P, Sander LE, Kurth F, Kreer C, Klein F.
Cell Host Microbe (2022)
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Viral load dyamics in SARS-CoV-2 Omicron breakthrough infections.
Dewald F, Detmer S, Pirkl M, Hellmich M, Heger E, Herrmann M, Zweigner J, Klein F.
J Infect Dis (2022)
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Effective high-throughput RT-qPCR screening for SARS-CoV-2 infections in children.
Dewald F, Suárez I, Johnen R, Grossbach J, Moran-Tovar R, Steger G, Joachim A, Rubio GH, Fries M, Behr F, Kley J, Lingnau A, Kretschmer A, Gude C, Baeza-Flores G, Del Valle DL, Roblero-Hernandez A, Magana-Cerino J, Hernandez AT, Ruiz-Quinones J, Schega K, Linne V, Junker L, Wunsch M, Heger E, Knops E, Di Cristanziano V, Meyer M, Hünseler C, Weber LT, Lüers JC, Quade G, Wisplinghoff H, Tiemann C, Zotz R, Jomaa H, Pranada A, Herzum I, Cullen P, Schmitz FJ, Philipsen P, Kirchner G, Knabbe C, Hellmich M, Buess M, Wolff A, Kossow A, Niessen J, Jeworutzki S, Schräpler JP, Lässig M, Dötsch J, Fätkenheuer G, Kaiser R, Beyer A, Rybniker J and Klein F
Nature Communication (2022)
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Antibody-mediated neutralization of SARS-CoV-2.
Gruell H, Vanshylla K, Weber T, Barnes CO, Kreer C, Klein F.
Immunity (2022)
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Effect of 3BNC117 and romidepsin on the HIV-1 reservoir in people taking suppressive antiretroviral therapy (ROADMAP): a randomised, open-label, phase 2A trial.
Gruell H, Gunst JD, Cohen YZ, Pahus MH, Malin JJ, Platten M, Millard KG, Tolstrup M, Jones RB, Conce Alberto WD, Lorenzi JCC, Oliveira TY, Kümmerle T, Suarez I, Unson-O'Brien C, Nogueira L, Olesen R, Ostergaard L, Nielsen H, Lehmann C, Nussenzweig MC, Fätkenheuer G, Klein F, Caskey M, Sogaard OS.
Lancet Microbe (2022)
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Cross-Variant Neutralizing Serum Activity after SARS-CoV-2 Breakthrough Infections.
Tober-Lau P, Gruell H, Vanshylla K, Koch WM, Hillus D, Schommers P, Suárez I, Suttorp N, Sander LE, Klein F, Kurth F.
Emerg Infect Dis. (2022)
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Determining the reliability of rapid SARS-CoV-2 antigen detection in fully vaccinated individuals.
Poopalasingam N, Korenkov M, Ashurov A, Strobel J, Fish I, Hellmich M, Gruell H, Lehmann C, Heger E, Klein F.
J Clin Virol. (2022)
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Durability of omicron-neutralising serum activity after mRNA booster immunisation in older adults.
Vanshylla K, Tober-Lau P, Gruell H, Münn F, Eggeling R, Pfeifer N, Le NH, Landgraf I, Kurth F, Sander LE, Klein F.
Lancet Infect Dis. (2022)
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No substantial preexisting B cell immunity against SARS-CoV-2 in healthy adults.
Ercanoglu MS, Gieselmann L, Dähling S, Poopalasingam N, Detmer S, Koch M, Korenkov M, Halwe S, Klüver M, Di Cristanziano V, Janicki H, Schlotz M, Worczinski J, Gathof B, Gruell H, Zehner M, Becker S, Vanshylla K, Kreer C, Klein F.
iScience (2022)
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mRNA booster immunization elicits potent neutralizing serum activity against the SARS-CoV-2 Omicron variant
Gruell H, Vanshylla K, Tober-Lau P, Hillus D, Schommers P, Lehmann C, Kurth F, Sander LE, Klein F.
Nature Medicine (2021)
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Complete list of publications
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2021 (selected publications)

Analysis of antibodies from HCV elite neutralizers identifies genetic determinants of broad neutralization
Weber T, Potthoff J, Bizu S, Labuhn M, Dold L, Schoofs T, Horning M, Ercanoglu MS, Kreer C, Gieselmann L, Vanshylla K, Langhans B, Janicki H, Ströh LJ, Knops E, Nierhoff D, Spengler U, Kaiser R, Bjorkman PJ, Krey T, Bankwitz D, Pfeifer N, Pietschmann T, Flyak AI, Klein F.
Immunity (2021)
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Discovery of ultrapotent broadly neutralizing antibodies from SARS-CoV-2 elite neutralizers
Vanshylla K, Fan C, Wunsch M, Poopalasingam N, Meijers M, Kreer C, Kleipass F, Ruchnewitz D, Ercanoglu MS, Gruell H, Münn F, Pohl K, Janicki H, Nolden T, Bartl S, Stein SC, Augustin M, Dewald F, Gieselmann L, Schommers P, Schulz TF, Sander LE, Koch M, Łuksza M, Lässig M, Bjorkman PJ, Klein F.
Cell Host & Microbe (2021)
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Safe and effective pool testing for SARS-CoV-2 detection
Wunsch M, Aschemeier D, Heger E, Ehrentraut D, Krüger J, Hufbauer M, Syed AS, Horemheb-Rubio G, Dewald F, Fish I, Schlotz M, Gruell H, Augustin M, Lehmann C, Kaiser R, Knops E, Silling S, Klein F.
J Clin Virol. (2021)
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Evaluation of a Rapid Antigen Test To Detect SARS-CoV-2 Infection and Identify Potentially Infectious Individuals
Korenkov M, Poopalasingam N, Madler M, Vanshylla K, Eggeling R, Wirtz M, Fish I, Dewald F, Gieselmann L, Lehmann C, Fätkenheuer G, Gruell H, Pfeifer N, Heger E, Klein F.
J Clin Microbiol. (2021)
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Effective high-throughput isolation of fully human antibodies targeting infectious pathogens
Gieselmann L, Kreer C, Ercanoglu MS, Lehnen N, Zehner M, Schommers P, Potthoff J, Gruell H, Klein F.
Nature Protocols (2021)
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Kinetics and correlates of the neutralizing antibody response to SARS-CoV-2 infection in humans
Vanshylla K, Di Cristanziano V, Kleipass F, Dewald F, Schommers P, Gieselmann L, Gruell H, Schlotz M, Ercanoglu MS, Stumpf R, Mayer P, Zehner M, Heger E, Johannis W, Horn C, Suárez I, Jung N, Salomon S, Eberhardt KA, Gathof B, Fätkenheuer G, Pfeifer N, Eggeling R, Augustin M, Lehmann C, Klein F.
Cell Host & Microbe (2021)
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CD34T+ Humanized Mouse Model to Study Mucosal HIV-1 Transmission and Prevention
Vanshylla K, Held K, Eser TM, Gruell H, Kleipass F, Stumpf R, Jain K, Weiland D, Münch J, Grüttner B, Geldmacher C, Klein F.
Vaccines (2021)
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Complete list of publications
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2020 (selected publications)

Longitudinal isolation of potent near-germline SARS-CoV-2-neutralizing antibodies from COVID-19 patients
Kreer C, Zehner M, Weber T, Ercanoglu MS, Gieselmann L, Rohde C, Halwe S, Korenkov M, Schommers P, Vanshylla K, Di Cristanziano V, Janicki H, Brinker R, Ashurov A, Krähling V, Kupke A, Cohen-Dvashi H, Koch M, Eckert JM, Lederer S, Pfeifer S, Wolf T, Vehreschild MJGT, Wendtner C, Diskin R, Gruell H, Becker S, Klein F.
Cell (2020)
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Antibody Teamwork against Ebola Virus Disease
Zehner M and Klein F.
Immunity (2020)
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Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody
Schommers P, Gruell H, Abernathy ME, Tran M-K, Dingens AS, Gristick HB, Barnes CO, Schoofs T, Schlotz M, Vanshylla K, Kreer C, Weiland D, Holtick U, Scheid C, Valter MV, van Gils MJ, Sanders RW, Vehreschild JJ, Cornely OA, Lehmann C, Fätkenheuer G, Seaman MS, Bloom JD, Bjorkman J, Klein F.
Cell (2020)
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OpenPrimeR for multiplex amplification of highly diverse templates
Kreer C, Döring M, Lehnen N, Ercanoglu MS, Gieselmann L, Luca D, Jain K, Schommers P, Pfeifer N, Klein F.
J Immunol Methods (2020)
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Exploiting B Cell Receptor Analyses to Inform on HIV-1 Vaccination Strategies
Kreer C, Gruell H, Mora T, Walczak A.M. and Klein F.
Vaccines (2020)
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Complete list of publications
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2019

Ehrhardt SA, Zehner M, Krähling V, Cohen-Dvashi H, Kreer C, Elad N, Gruell H, Ercanoglu MS, Schommers P, Gieselmann L, Eggeling R, Dahlke C, Wolf T, Pfeifer N, Addo MM, Diskin R, Becker S, Klein F. Polyclonal and convergent antibody response to Ebola virus vaccine rVSV-ZEBOV.
Nat Med (2019)
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Döring M, Kreer C, Lehnen N, Klein F, Pfeifer N. Modeling the Amplification of Immunoglobulins through Machine Learning on Sequence-Specific Features.
Sci Rep. (2019)
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Schleimann MH, Kobberø ML, Vibholm LK, Kjær K, Giron LB, Busman-Sahay K, Chan CN, Nekorchuk M, Schmidt M, Wittig B, Damsgaard TE, Ahlburg P, Hellfritzsch MB, Zuwala K, Rothemejer FH, Olesen R, Schommers P, Klein F, Dweep H, Kossenkov A, Nyengaard JR, Estes JD, Abdel-Mohsen M, Østergaard L, Tolstrup M, Søgaard OS, Denton PW. TLR9 agonist MGN1703 enhances B cell differentiation and function in lymph nodes.
EBioMedicine. (2019)
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Schoofs T, Barnes CO, Suh-Toma N, Golijanin J, Schommers P, Gruell H, West AP Jr, Bach F, Lee YE, Nogueira L, Georgiev IS, Bailer RT, Czartoski J, Mascola JR, Seaman MS, McElrath MJ, Doria-Rose NA, Klein F, Nussenzweig MC, Bjorkman PJ. Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope.
Immunity. (2019)
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Stecher M, Claßen A, Klein F, Lehmann C, Gruell H, Platten M, Wyen C, Behrens G, Fätkenheuer G, Vehreschild JJ. Systematic Review And Meta-Analysis of Treatment Interruptions in HIV-1 Infected Patients Receiving Antiretroviral Therapy: Implications for Future HIV Cure Trials.
Clin Infect Dis.. (2019)
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Caskey M, Klein F, Nussenzweig MC. Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic.
Nat Med. (2019)
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2018

Gruell H and Klein F. Antibody-mediated prevention and treatment of HIV-1 infection.
Retrovirology. (2018)
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Khera T, Behrendt P, Bankwitz D, Brown RJP, Todt D, Doepke M, Ghafoor Khan A, Schulze K, Law J, Logan M, Hockman D, Wong JAJ, Dold L, Gonzalez-Motos V, Spengler U, Viejo-Borbolla A, Ströh L, Krey T, Tarr AW, Steinmann E, Manns MP, Klein F, Guzman CA, Marcotrigiano J, Houghton M, Pietschmann T. Functional and immunogenic characterization of diverse HCV glycoprotein E2 variants.
J Hepatol. (2018)
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Lu CL, Pai JA, Nogueira L, Mendoza P, Gruell H, Oliveira TY, Barton J, Lorenzi JCC, Cohen YZ, Cohn LB, Klein F, Caskey M, Nussenzweig MC, Jankovic M. Relationship between intact HIV-1 proviruses in circulating CD4+ T cells and rebound viruses emerging during treatment interruption.
PNAS. (2018)
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Bar-On Y, Gruell H, Schoofs T, Pai JA, Nogueira L, Butler AL, Millard K, Lehmann C, Suárez I, Oliveira TY, Karagounis T, Cohen YZ, Wyen C, Scholten S, Handl L, Belblidia S, Dizon JP, Vehreschild JJ, Witmer-Pack M, Shimeliovich I, Jain K, Fiddike K, Seaton KE, Yates NL, Horowitz J, Gulick RM, Pfeifer N, Tomaras GD, Seaman MS, Fätkenheuer G, Caskey M, Klein F, Nussenzweig MC*. Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals.
Nat Med. (2018)
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Mendoza P, Gruell H, Nogueira L, Pai JA, Butler AL, Millard K, Lehmann C, Suárez I, Oliveira TY, Lorenzi JCC, Cohen YZ, Wyen C, Kümmerle T, Karagounis T, Lu CL, Handl L, Unson-O'Brien C, Patel R, Ruping C, Schlotz M, Witmer-Pack M, Shimeliovich I, Kremer G, Thomas E, Seaton KE, Horowitz J, West AP Jr, Bjorkman PJ, Tomaras GD, Gulick RM, Pfeifer N, Fätkenheuer G, Seaman MS, Klein F, Caskey M, Nussenzweig MC*. Combination therapy with anti-HIV-1 antibodies maintains viral suppression.
Nature. (2018)
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Meder L, König K, Dietlein F, Macheleidt I, Florin A, Ercanoglu MS, Rommerscheidt-Fuss U, Koker M, Schön G, Odenthal M, Klein F, Büttner R, Schulte JH, Heukamp LC, Ullrich RT., LIN28B enhanced tumorigenesis in an autochthonous KRASG12V-driven lung carcinoma mouse model.
Oncogene. (2018)
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2017

Nishimura Y., Gautam R., Chun T.W., Sadjadpour R., Foulds K.E., Shingai M., Klein F., Gazumyan A., Golijanin J., Donaldson M., Donau O.K., Plishka R.J., Buckler-White A., Seaman M.S., Lifson J.D., Koup R.A., Fauci A.S., Nussenzweig M.C., Martin M.A., Early antibody therapy can induce long-lasting immunity to SHIV.
Nature. (2017). read more

Gruell H. and Klein F., Progress in HIV-1 antibody research using humanized mice.
Curr Opin HIV AIDS. (2017). readmore

Caskey M., Schoofs T., Gruell H., Settler A., Karagounis T., Kreider E.F., Murrell B., Pfeifer N., Nogueira L., Oliveira T.Y., Learn G.H., Cohen Y.Z., Lehmann C., Gillor D., Shimeliovich I., Unson-O’Brien C., Weiland D., Robles A., Kümmerle T., Wyen C., Levin R., Witmer-Pack M., Eren K., Ignacio C., Kiss S., West A.P., Mouquet H., Zingman B.S., Gulick R.M., Keler T., Bjorkman P.J., Seaman M.S., Hahn B.H., Fätkenheuer G., Schlesinger S.J., Nussenzweig M.C., Klein F.*, Antibody 10-1074 suppresses viremia in HIV-1-infected individuals.
Nat Med. (2017). read more

2016

Caskey, M., Klein, F., Nussenzweig, M.C., Broadly Neutralizing Antibodies for HIV-1 Prevention or Immunotherapy.
N Engl J Med. (2016). read more

Gristick, H.B., von Boehmer, L., West, A.P. Jr, Schamber, M., Gazumyan, A., Golijanin, J., Seaman, M.S., Fätkenheuer, G., Klein, F., Nussenzweig, M.C., Bjorkman, P.J.,. Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4- binding site.
Nat Struct Mol Biol. (2016). read more

Scheid, J.F., Horwitz, J.A., Bar-On, Y., Kreider, E.F., Lu, C.L., Lorenzi, J.C., Feldmann, A., Braunschweig, M., Nogueira, L., Oliveira, T., Shimeliovich, I., Patel, R., Burke, L., Cohen, Y.Z., Hadrigan, S., Settler, A., Witmer-Pack, M., West, A.P. Jr, Juelg, B., Keler, T., Hawthorne, T., Zingman, B., Gulick, R.M., Pfeifer, N., Learn, G.H., Seaman, M.S., Bjorkman, P.J., Klein, F., Schlesinger, S.J., Walker, B.D., Hahn, B.H., Nussenzweig, M.C., HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption.
Nature. (2016). read more

Schoofs, T., Klein, F., Braunschweig, M.*, Kreider, E.F., Feldmann, A., Nogueira, L., Oliveira, T., Lorenzi, J.C., Parrish, E.H., Learn, G.H., West, A.P. Jr, Bjorkman, P.J., Schlesinger, S.J., Seaman, M.S., Czartoski, J., McElrath, M.J., Pfeifer, N., Hahn, B.H., Caskey, M., Nussenzweig, M.C., HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1.
Science. (2016). read more

Gautam, R., Nishimura, Y., Pegu, A., Nason, M.C., Klein, F., Gazumyan, A., Golijanin, J., Buckler-White, A., Sadjadpour, R., Wang, K., Mankoff, Z., Schmidt, S.D., Lifson, J.D., Mascola, J.R., Nussenzweig, M.C., Martin, M.A., A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges.
Nature. (2016). read more

Akkina, R.K., Allam, A., Balazs, A.B., Blankson, J., Burnett, J.C., Casares, S., Garcia, J.V., Hasenkrug, K., Kashanchi, F., Kitchen, S., Klein, F., Kumar, P., Luster, A.D., Poluektova, L.Y., Rao, M., Sanders, B.E., Shultz, L.D., and JA, Z., Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary.
AIDS Res Hum Retroviruses. (2016). read more

2015

Lee, J.H., Leaman, D.P., Kim, A.S., Torrents de la Pena, A., Sliepen, K., Yasmeen, A., Derking, R., Ramos, A., de Taeye, S.W., Ozorowski, G., Klein, F., Burton, D.R., Nussenzweig, M.C., Poignard, P., Moore, J.P., Klasse, P.J., Sanders, R.W., Zwick, M.B., Wilson, I.A., and Ward, A.B., Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike.
Nat Commun (2015). read more

Cohn, L.B., Silva, I.T., Oliveira, T.Y., Rosales, R.A., Parrish, E.H., Learn, G.H., Hahn, B.H., Czartoski, J.L., McElrath, M.J., Lehmann, C., Klein, F., Caskey, M., Walker, B.D., Siliciano, J.D., Siliciano, R.F., Jankovic, M., and Nussenzweig, M.C., HIV-1 integration landscape during latent and active infection.
Cell. (2015). read more

Gruell, H. and Klein, F., Mögliche Strategien zur HIV-Prävention und -Therapie.
MMW Fortschr Med. (2015).

Freund, N.T., Horwitz, J.A., Nogueira, L., Sievers, S.A., Scharf, L., Scheid, J.F., Gazumyan, A., Liu, C., Velinzon, K., Goldenthal, A., Sanders, R.W., Moore, J.P., Bjorkman, P.J., Seaman, M.S., Walker, B.D., Klein, F., and Nussenzweig, M.C., A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo.
PLoS Pathog. (2015). read more

Caskey, M., Klein, F., Lorenzi, J.C., Seaman, M.S., West, A.P., Jr., Buckley, N., Kremer, G., Nogueira, L., Braunschweig, M., Scheid, J.F., Horwitz, J.A., Shimeliovich, I., Ben-Avraham, S., Witmer-Pack, M., Platten, M., Lehmann, C., Burke, L.A., Hawthorne, T., Gorelick, R.J., Walker, B.D., Keler, T., Gulick, R.M., Fatkenheuer, G., Schlesinger, S.J., and Nussenzweig, M.C., Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117.
Nature. (2015). read more

Zolla-Pazner, S., Cohen, S.S., Boyd, D., Kong, X.P., Seaman, M., Nussenzweig, M., Klein, F., Overbaugh, J., and Totrov, M., Structure/Function Studies Involving the V3 Region of the HIV-1 Envelope Delineate Multiple Factors that Affect Neutralization Sensitivity.
J Virol. (2015). read more

2014

Bournazos, S., Klein, F., Pietzsch, J., Seaman, M.S., Nussenzweig, M.C., and Ravetch, J.V., Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in vivo activity.
Cell. (2014). read more

Halper-Stromberg, A., Lu, C.L., Klein, F., Horwitz, J.A., Bournazos, S., Nogueira, L., Eisenreich, T.R., Liu, C., Gazumyan, A., Schaefer, U., Furze, R.C., Seaman, M.S., Prinjha, R., Tarakhovsky, A., Ravetch, J.V., and Nussenzweig, M.C., Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice.
Cell. (2014). read more

Klein, F., Nogueira, L., Nishimura, Y., Phad, G., West, A.P., Jr., Halper-Stromberg, A., Horwitz, J.A., Gazumyan, A., Liu, C., Eisenreich, T.R., Lehmann, C., Fatkenheuer, G., Williams, C., Shingai, M., Martin, M.A., Bjorkman, P.J., Seaman, M.S., Zolla-Pazner, S., Karlsson Hedestam, G.B., and Nussenzweig, M.C., Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants.
J Exp Med. (2014). read more

Gruell, H. and Klein, F., Opening Fronts in HIV Vaccine Development: Tracking the development of broadly neutralizing antibodies.
Nat Med. (2014). read more

West, A.P., Jr., Scharf, L., Scheid, J.F., Klein, F., Bjorkman, P.J., and Nussenzweig, M.C., Structural insights on the role of antibodies in HIV-1 vaccine and therapy.
Cell. (2014). read more

Shingai, M., Donau, O.K., Plishka, R.J., Buckler-White, A., Mascola, J.R., Nabel, G.J., Nason, M.C., Montefiori, D., Moldt, B., Poignard, P., Diskin, R., Bjorkman, P.J., Eckhaus, M.A., Klein, F., Mouquet, H., Cetrulo Lorenzi, J.C., Gazumyan, A., Burton, D.R., Nussenzweig, M.C., Martin, M.A., and Nishimura, Y., Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques.
J Exp Med. (2014). read more

2013

Klein, F., Mouquet, H., Dosenovic, P., Scheid, J.F., Scharf, L., and Nussenzweig, M.C., Antibodies in HIV-1 vaccine development and therapy.
Science. (2013). read more

Shingai, M., Nishimura, Y., Klein, F., Mouquet, H., Donau, O.K., Plishka, R., Buckler-White, A., Seaman, M., Piatak, M., Jr., Lifson, J.D., Dimitrov, D.S., Nussenzweig, M.C., and Martin, M.A., Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia.
Nature. (2013). read more

Klein, F., Diskin, R., Scheid, J.F., Gaebler, C., Mouquet, H., Georgiev, I.S., Pancera, M., Zhou, T., Incesu, R.B., Fu, B.Z., Gnanapragasam, P.N., Oliveira, T.Y., Seaman, M.S., Kwong, P.D., Bjorkman, P.J., and Nussenzweig, M.C., Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization.
Cell. (2013). read more

Malbec, M., Porrot, F., Rua, R., Horwitz, J., Klein, F., Halper-Stromberg, A., Scheid, J.F., Eden, C., Mouquet, H., Nussenzweig, M.C., and Schwartz, O., Broadly neutralizing antibodies that inhibit HIV-1 cell to cell transmission.
J Exp Med. (2013). read more

West, A.P., Jr., Scharf, L., Horwitz, J., Klein, F., Nussenzweig, M.C., and Bjorkman, P.J., Computational analysis of anti-HIV-1 antibody neutralization panel data to identify potential functional epitope residues.
Proc Natl Acad Sci U S A. (2013). read more

Diskin, R., Klein, F., Horwitz, J.A., Halper-Stromberg, A., Sather, D.N., Marcovecchio, P.M., Lee, T., West, A.P., Jr., Gao, H., Seaman, M.S., Stamatatos, L., Nussenzweig, M.C., and Bjorkman, P.J., Restricting HIV-1 pathways for escape using rationally designed anti-HIV-1 antibodies.
J Exp Med. (2013). read more

Barouch, D.H., Whitney, J.B., Moldt, B., Klein, F., Oliveira, T.Y., Liu, J., Stephenson, K.E., Chang, H.W., Shekhar, K., Gupta, S., Nkolola, J.P., Seaman, M.S., Smith, K.M., Borducchi, E.N., Cabral, C., Smith, J.Y., Blackmore, S., Sanisetty, S., Perry, J.R., Beck, M., Lewis, M.G., Rinaldi, W., Chakraborty, A.K., Poignard, P., Nussenzweig, M.C., and Burton, D.R., Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys.
Nature. (2013). read more

Horwitz, J.A., Halper-Stromberg, A., Mouquet, H., Gitlin, A.D., Tretiakova, A., Eisenreich, T.R., Malbec, M., Gravemann, S., Billerbeck, E., Dorner, M., Buning, H., Schwartz, O., Knops, E., Kaiser, R., Seaman, M.S., Wilson, J.M., Rice, C.M., Ploss, A., Bjorkman, P.J., Klein, F., and Nussenzweig, M.C., HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice.
Proc Natl Acad Sci U S A. (2013). read more

Hoot, S., McGuire, A.T., Cohen, K.W., Strong, R.K., Hangartner, L., Klein, F., Diskin, R., Scheid, J.F., Sather, D.N., Burton, D.R., and Stamatatos, L., Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bNAbs.
PLoS Pathog. (2013). read more

Guermonprez, P., Helft, J., Claser, C., Deroubaix, S., Karanje, H., Gazumyan, A., Darasse-Jeze, G., Telerman, S.B., Breton, G., Schreiber, H.A., Frias-Staheli, N., Billerbeck, E., Dorner, M., Rice, C.M., Ploss, A., Klein, F., Swiecki, M., Colonna, M., Kamphorst, A.O., Meredith, M., Niec, R., Takacs, C., Mikhail, F., Hari, A., Bosque, D., Eisenreich, T., Merad, M., Shi, Y., Ginhoux, F., Renia, L., Urban, B.C., and Nussenzweig, M.C., Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection.
Nat Med. (2013). read more

Gaebler, C., Gruell, H., Velinzon, K., Scheid, J.F., Nussenzweig, M.C., and Klein, F., Isolation of HIV-1-reactive antibodies using cell surface-expressed gp160Deltac(BaL.).
J Immunol Methods. (2013). read more

2012

Pietzsch, J., Gruell, H., Bournazos, S., Donovan, B.M., Klein, F., Diskin, R., Seaman, M.S., Bjorkman, P.J., Ravetch, J.V., Ploss, A., and Nussenzweig, M.C., A mouse model for HIV-1 entry.
Proc Natl Acad Sci U S A. (2012). read more

Klein, F., Gaebler, C., Mouquet, H., Sather, D.N., Lehmann, C., Scheid, J.F., Kraft, Z., Liu, Y., Pietzsch, J., Hurley, A., Poignard, P., Feizi, T., Morris, L., Walker, B.D., Fatkenheuer, G., Seaman, M.S., Stamatatos, L., and Nussenzweig, M.C., Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein.
J Exp Med. (2012). read more

Klein, F., Halper-Stromberg, A., Horwitz, J.A., Gruell, H., Scheid, J.F., Bournazos, S., Mouquet, H., Spatz, L.A., Diskin, R., Abadir, A., Zang, T., Dorner, M., Billerbeck, E., Labitt, R.N., Gaebler, C., Marcovecchio, P.M., Incesu, R.B., Eisenreich, T.R., Bieniasz, P.D., Seaman, M.S., Bjorkman, P.J., Ravetch, J.V., Ploss, A., and Nussenzweig, M.C., HIV therapy by a combination of broadly neutralizing antibodies in humanized mice.
Nature. (2012). read more

Vehreschild, J.J., Moritz, G., Vehreschild, M.J., Arenz, D., Mahne, M., Bredenfeld, H., Chemnitz, J., Klein, F., Cremer, B., Boll, B., Kaul, I., Wassmer, G., Hallek, M., Scheid, C., and Cornely, O.A., Efficacy and safety of moxifloxacin as antibacterial prophylaxis for patients receiving autologous haematopoietic stem cell transplantation: a randomised trial.
Int J Antimicrob Agents. (2012). read more

Sather, D.N., Carbonetti, S., Kehayia, J., Kraft, Z., Mikell, I., Scheid, J.F., Klein, F., and Stamatatos, L., Broadly neutralizing antibodies developed by an HIV-positive elite neutralizer exact a replication fitness cost on the contemporaneous virus.
J Virol. (2012). read more

2011

Scheid, J.F., Mouquet, H., Ueberheide, B., Diskin, R., Klein, F., Oliveira, T.Y., Pietzsch, J., Fenyo, D., Abadir, A., Velinzon, K., Hurley, A., Myung, S., Boulad, F., Poignard, P., Burton, D.R., Pereyra, F., Ho, D.D., Walker, B.D., Seaman, M.S., Bjorkman, P.J., Chait, B.T., and Nussenzweig, M.C., Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding.
Science. (2011). read more

Mouquet, H., Klein, F., Scheid, J.F., Warncke, M., Pietzsch, J., Oliveira, T.Y., Velinzon, K., Seaman, M.S., and Nussenzweig, M.C., Memory B cell antibodies to HIV-1 gp140 cloned from individuals infected with clade A and B viruses.
PLoS One. (2011). read more

Diskin, R., Scheid, J.F., Marcovecchio, P.M., West, A.P., Jr., Klein, F., Gao, H., Gnanapragasam, P.N., Abadir, A., Seaman, M.S., Nussenzweig, M.C., and Bjorkman, P.J., Increasing the potency and breadth of an HIV antibody by using structure-based rational design.
Science. (2011). read more

2010

Pietzsch, J., Scheid, J.F., Mouquet, H., Klein, F., Seaman, M.S., Jankovic, M., Corti, D., Lanzavecchia, A., and Nussenzweig, M.C., Human anti-HIV-neutralizing antibodies frequently target a conserved epitope essential for viral fitness.
J Exp Med. (2010). read more

2009

Klein, F. and Hallek, M., Does the removal of non-affected lymph nodes of a neoplastic focus weaken the immunologic defense?.
Dtsch Med Wochenschr. (2009). read more

2007

Feldhahn, N., Henke, N., Melchior, K., Duy, C., Soh, B.N., Klein, F., von Levetzow, G., Giebel, B., Li, A., Hofmann, W.K., Jumaa, H., and Muschen, M., Activation-induced cytidine deaminase acts as a mutator in BCR-ABL1-transformed acute lymphoblastic leukemia cells.
J Exp Med. (2007). read more

2006

Klein, F., Feldhahn, N., Herzog, S., Sprangers, M., Mooster, J.L., Jumaa, H., and Muschen, M., BCR-ABL1 induces aberrant splicing of IKAROS and lineage infidelity in pre-B lymphoblastic leukemia cells.
Oncogene. (2006). read more

2005

Feldhahn, N., Klein, F., Mooster, J.L., Hadweh, P., Sprangers, M., Wartenberg, M., Bekhite, M.M., Hofmann, W.K., Herzog, S., Jumaa, H., Rowley, J.D., and Muschen, M., Mimicry of a constitutively active pre-B cell receptor in acute lymphoblastic leukemia cells.
J Exp Med. (2005). read more

Feldhahn, N., Rio, P., Soh, B.N., Liedtke, S., Sprangers, M., Klein, F., Wernet, P., Jumaa, H., Hofmann, W.K., Hanenberg, H., Rowley, J.D., and Muschen, M., Deficiency of Bruton's tyrosine kinase in B cell precursor leukemia cells.
Proc Natl Acad Sci U S A. (2005). read more

Soh, B.N., Klein, F., Feldhahn, N., and Muschen, M., B-lymphoid or myeloid lineage identity of cell lines derived from chronic myeloid leukemia blast crisis.
Cancer Genet Cytogenet. (2005). read more

Klein, F., Feldhahn, N., Mooster, J.L., Sprangers, M., Hofmann, W.K., Wernet, P., Wartenberg, M., and Muschen, M., Tracing the pre-B to immature B cell transition in human leukemia cells reveals a coordinated sequence of primary and secondary IGK gene rearrangement, IGK deletion, and IGL gene rearrangement.
J Immunol. (2005). read more

Klein, F., Feldhahn, N., and Muschen, M., Interference of BCR-ABL1 kinase activity with antigen receptor signaling in B cell precursor leukemia cells.
Cell Cycle. (2004). read more

Klein, F., Feldhahn, N., Harder, L., Wang, H., Wartenberg, M., Hofmann, W.K., Wernet, P., Siebert, R., and Muschen, M., The BCR-ABL1 kinase bypasses selection for the expression of a pre-B cell receptor in pre-B acute lymphoblastic leukemia cells.
J Exp Med. (2004). read more

2003

Klein, F., Feldhahn, N., Lee, S., Wang, H., Ciuffi, F., von Elstermann, M., Toribio, M.L., Sauer, H., Wartenberg, M., Barath, V.S., Kronke, M., Wernet, P., Rowley, J.D., and Muschen, M., T lymphoid differentiation in human bone marrow.
Proc Natl Acad Sci U S A. (2003). read more

Wartenberg, M., Ling, F.C., Muschen, M., Klein, F., Acker, H., Gassmann, M., Petrat, K., Putz, V., Hescheler, J., and Sauer, H., Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species.
FASEB J. (2003). rea