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Perspective on Broadly neutralizing Antibodies

Broadly Neutralizing Antibodies for HIV-1 Prevention or Immunotherapy

Caskey M., Klein F., Nussenzweig M.C.

Despite tremendous efforts to prevent transmission of human immunodeficiency virus type 1 (HIV-1), new infections and AIDS-related deaths continue to be a global problem. Antiretroviral therapy (ART) can effectively suppress HIV-1 replication and limit disease progression. However, ART fails to eradicate the virus, and suppression requires lifelong therapy, which may have side effects and poses a risk of the development of resistance. New approaches to preventing and treating HIV-1 infection are therefore necessary to contain the epidemic and to bolster nascent efforts to find a cure. N Eng J Med, 11/9/2016