Felix paper on viral load dynamics in SARS-CoV-2 Omicron breakthrough infections is online now.

In order to determine viral dynamics in Omicron breakthrough infections, we measured SARS-CoV-2 RNA in 206 double vaccinated or boostered individuals. During the first three days following the onset of symptoms, viral loads were significantly higher (Ct 21.76) in vaccinated compared to boostered (Ct 23.14) individuals (p = 0.029). However, by performing a longitudinal analysis on 32 individuals over 14 days, no difference in the viral load trajectory was observed between double vaccinated and boostered patients. Our results indicate that booster immunization results in a small reduction in detectable viral loads without significantly changing viral load dynamics over time.